Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure

Results

Reduced iron content, IRE binding activity, and transferrin receptor expression in the failing human heart

pvalue <- 0.00152894

boxplot(w1$vals,

      main='Leaf BioMass in High CO2 Environment',
      ylab='BioMass of Leaves')

Consistent with previous reports {cite}maeder2011,leszek2012 iron concentration was significantly lower in LV tissue samples from patients with advanced heart failure than in LV tissue samples from unused donor hearts. As shown by electrophoretic mobility shift assays, IRE binding activity was significantly (p < formatC(pvalue,3,format="f") ) reduced in failing hearts (most pronounced in patients with ischemic cardiomyopathy) ({ref}Figure 1<fig1>). Protein expression levels of the transferrin receptor were significantly lower in failing hearts than in the controls.